1Department of Nuclear Medicine, Christian Medical College, Vellore, Tamil Nadu, India2Department of Hematology, Christian Medical College, Vellore, Tamil Nadu, India3Department of Radiodiagnosis, Christian Medical College, Vellore, Tamil Nadu, India, Correspondence Address:Dr. Regi OommenDepartment of Nuclear Medicine, Christian Medical College, Vellore - 632 004, Tamil Nadu IndiaSource of Support: None, Conflict of Interest: NoneCheckDOI:10.4103/ijnm.ijnm_102_22 function RightsLinkPopUp () { var url = "https://s100.copyright.com/AppDispatchServlet"; var location = url + "?publisherName=" + encodeURI ('Medknow') + "&publication=" + encodeURI ('IJNM') + "&title=" + encodeURI ('Validation of deauville score for response evaluation in hodgkin's lymphoma') + "&publicationDate=" + encodeURI ('Jan 1 2023 12:00AM') + "&author=" + encodeURI ('John JR, Oommen R, Hephzibah J, Mathew D, Korula A, Shanthly N, Eapen A') + "&contentID=" + encodeURI ('IndianJNuclMed_2023_38_1_16_370409') + "&orderBeanReset=true" Lymphoma is a group of malignant neoplasms of lymphocytes with more than 90 subtypes. Published by Wolters Kluwer -. Score 3 should be interpreted according to the clinical context but in many Hodgkin Lymphoma patients indicates a good A Feature Knogler, T., El-Rabadi, K., Weber, M., Karanikas, G. & Mayerhoefer, M. E. Three-dimensional texture analysis of contrast enhanced CT images for treatment response assessment in Hodgkin lymphoma: Comparison with F-18-FDG PET. Rep. 11, 23812. https://doi.org/10.1038/s41598-021-03278-9 (2021). The median age of patients at diagnosis of non-Hodgkin lymphoma is 67 years, and the median age at death is 76. The 1 year PFS was 93.3% and no patient had Nodal Pathologic Complete Response Rates in Luminal Breast Cancer Vary by Genomic Risk. A total of 128 patients with pathological grade 12 received multiple mild treatments and 91 patients with pathological grade 3a received rituximab-based systemic chemotherapy. Slider with three articles shown per slide. It furthermore was the only feature that remained in both datasets after applying different feature reduction techniques. The study was designed to test if the PET-negative rate after two cycles of BV-AVD was superior to 75%. Outcome analysis of high-dose chemotherapy and autologous stem cell transplantation in adolescent and young adults with relapsed or refractory Hodgkin lymphoma. An open lymph node biopsy is preferred for diagnosis. Research reported in this article was supported by the National Institute of General Medical Sciences of the National Institutes of Health under award number 5U54GM104942-03. The metabolic activity in PET/CT is usually assessed with the Deauville Score (DS), a 5-point system to categorize FDG avidity. MDPI and/or Correlation between SUVmax and CT radiomic analysis using lymph node density in PET/CT-based lymph node staging. Radiol. suggested a link between the non-contrast-enhanced CT-derived texture parameter kurtosis and shorter progression-free survival of lymphoma patients in an 18F-FDG-PET/CT study, including patients with Hodgkin lymphoma and aggressive Non-Hodgkin lymphoma14. Since these are acquired shortly before the PET images, this results in only a short temporal gap to the reference standard. Conceptualization, F.I. Leuk. ; Amthauer, H.; Mller, H.W. Cheson, B. D. et al. Isik, E.G. We further determined the diagnostic performance of each feature to classify a lesion as DS4-positive or DS4-negative with the receiver operating characteristic (ROC) curve analysis using the pROC package29 (Version 1.18.0). We included a total of 75 PET/CT datasets acquired in 43 patients. 18F-FDG-PET/CT is standard to assess response in Hodgkin lymphoma by quantifying metabolic activity with the Deauville score. If a relapse occurred at a new site, we classified the examination as "initial". Rep. 11, 2055. https://doi.org/10.1038/s41598-021-81526-8 (2021). We aimed to compare the performance of Positron emission tomography-computed tomography standardized uptake values in clinical practice and assessing response to therapy. Patients should follow up with an oncologist every three to six months for the first two years, every six to 12 months until year 3, then annually thereafter. Cheson, B. D. PET/CT in Lymphoma: Current overview and future directions. Rep. 10, 11649. https://doi.org/10.1038/s41598-020-68310-w (2020). doi: 10.1016/S2352-3026(21)00102-2. ; Mauch, P.M. ; methodology, F.I. Bethesda, MD 20894, Web Policies Four of these features overlapped: mean, median, RMS, and 90th percentile. van Griethuysen, J. J. M. et al. Required fields are marked *. PET scan followed after a median uptake time of 68min (IQR, 63.576.5min). Lancet. ; Cavalli, F.; Schwartz, L.H. Semin. Imaging in staging of malignant lymphoma: A systematic review. The left row shows the AUCs of Scanner A, and the right row the AUCs of Scanner B. This articledid not receive any funding. 86, 420428. Med. https://doi.org/10.1007/s11307-022-01703-7 (2022). Keywords:Deauville score, F-18 fluorodeoxyglucose positron emission tomography-computed tomography, Hodgkin's lymphoma. Long-term cause specific mortality of patients treated for Hodgkins disease. In their approach, Giesel et al. Based on the type of response at interim evaluation, patients showing a complete metabolic There were 15 datasets per patient (scanner A: 10 patients with 1 scan, 11 patients with 2 scans, 3 patients with 3 scans, 2 patients with 5 scans and scanner B: 11 patients with 1 scan, 5 patients with 2 scans, 1 patient with 3 scans). J Clin Oncol. ; Weller, E.; Backstrand, K.H. ; Mikhaeel, N.G. Federal government websites often end in .gov or .mil. Context: Positron emission tomography (PET) using F-18 fluorodeoxyglucose (FDG) for treatment monitoring in patients with lymphoma is one of the most well-developed clinical applications. ; Cioni, D.; Neri, E. Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma? Your email address will not be published. Psychol. Kinahan PE, Fletcher JW. Scores of 1 and 2 are considered to be negative and 4 and 5 are considered to be positive. Hodgkin lymphoma in childhoodClinicopathological features and therapy outcome at 2 centres from a developing country. AJR Am J Roentgenol 2019;212:456-60. The first-order texture feature median describing lesion density derived from NECT concordantly has a high sensitivity for DS4+ Hodgkin manifestations on two different scanners. Article In these scans we manually marked the previously defined target lesion with a three-dimensional ROI (3D ROI) using 3D Slicer (22, 3D Slicer, Version 4.10.0, http://www.slicer.org). Oncol. Sci Rep 12, 20008 (2022). This cutoff is of the highest relevance7,8. The generalizability and clinical applicability should be evaluated on data from a second PET/CT scanner. and B.H. To assess reproducibility by other readers, intraclass correlation coefficients (ICCs) were further calculated scanner-wise for each feature. Household contacts should receive appropriate CDC-recommended immunizations.43, This article updates a previous article on this topic by Glass.46. 7, Ganeshan et al. Systemic symptoms of fever, unexplained weight loss, and night sweats occur in a subset of patients with more advanced disease. Med. Results: Among 212 scans assigned DS, 165 scans showed agreement between the DS and line of treatment. MeSH Northwestern University, Evanston, Illinois. Conclusion: Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for 3D Slicer as an image computing platform for the Quantitative Imaging Network. It is traditionally classified broadly as non-Hodgkin or Hodgkin lymphoma. PubMed Central WebNeurolymphomatosis: an uncommon manifestation of lymphoma detection and therapeutic monitoring through 18F-fluorodeoxyglucose positron-emission tomography and computed tomography imaging. WebHe got quite a large lump on his right shoulder prior to chemotherapy and after the treatment, the lump could not be seen visibly. In a multivariable analysis, we identified two independent factors predicting treatment failure: pretransplant DS combined with rMTV41% and disease status (primary refractory vs. relapsed). the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, 1993;341(8852):1051-1054. Hodgkin's lymphoma. BREACH is a multicenter, randomized, open-label, phase II trial. Skoetz N, Will A, Monsef I, Brillant C, Engert A, von Tresckow B. Cochrane Database Syst Rev. Disclaimer. Between March 2015 and October 2016, 170 patients were enrolled. 32, 30593068. https://doi.org/10.1007/s00330-016-4470-8 (2017). ; Fisher, R.I.; Barrington, S.F. BV-AVD demonstrated an improvement in the PET-negative rate compared with ABVD after two cycles. Diagnostic value of baseline (18)FDG PET/CT skeletal textural features in follicular lymphoma. Dr. Julian Rogasch is participant in the BIH-Charit Digital Clinician Scientist Program funded by the Charit Universittsmedizin Berlin, the Berlin Institute of Health, and the German Research Foundation (DFG). Early interim FDG PET/CT prediction of treatment response and prognosis in pediatric Hodgkin disease-added value of low-dose CT. Kluge, R.; Kurch, L.; Georgi, T.; Metzger, M. Current role of FDG-PET in pediatric Hodgkins lymphoma. We also searched the Agency for Healthcare Research and Quality evidence reports, UpToDate, the Cochrane database, Essential Evidence Plus, the National Comprehensive Cancer Network, and the Surveillance, Epidemiology, and End Results database. J. Nucl. Bull. Cumulative burden of cardiovascular morbidity in paediatric, adolescent, and young adult survivors of Hodgkins lymphoma: An analysis from the St Jude Lifetime Cohort Study. Author disclosure: No relevant financial affiliations. Asthana, S.; Labani, S.; Mehrana, S.; Bakhshi, S. Incidence of childhood leukemia and lymphoma in India. Subsequent chemotherapy toxicities include neuropathy, cardiotoxicity, and secondary cancers such as lung and breast, and should be considered in the shared decision-making process to select a treatment regimen. Radiology 288, 407415. those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). Lancet Oncol. Google Scholar. government site. https://doi.org/10.1182/blood-2018-05-852129 (2018). Reproducibility of radiomics is a general concern, restraining the implementation of radiomic signatures into clinical routine37. Pretransplant DS was determined as 1-3 (59%) and 4-5 (41%), with a markedly inferior event-free survival (EFS) in patients with DS 4-5 (hazard ratio [HR], 3.14; p = .002). Patients were followed up with clinical examinations and biochemical tests (including serum LDH levels). This content is owned by the AAFP. Annunziata, S.; Cuccaro, A.; Calcagni, M.L. Scatter correction, randoms correction, and dead time correction were also performed. The International Prognostic Index is used broadly for all subtypes of non-Hodgkin lymphoma, and the International Prognostic Score is used for Hodgkin lymphoma20,21 (Table 422,23). Younes A, Santoro A, Shipp M, et al. and T.E. For example, Mayerhoefer et al. sharing sensitive information, make sure youre on a federal Cancers (Basel) 13. https://doi.org/10.3390/cancers13143634 (2021). The most common subtype, diffuse large B-cell lymphoma, has a 40% lifetime relapse rate.37 Lifetime relapse in Hodgkin lymphoma occurs in 10% to 15% of patients with early stage disease and 40% of patients with advanced stage disease.38, Patients who have achieved remission need routine surveillance to monitor for complications and relapse, as well as age-appropriate screenings recommended by the U.S. Preventive Services Task Force.39 Complications of lymphoma treatment include secondary malignancies (e.g., breast, lung, skin, colon), cardiac disease, infertility, and endocrine, neurologic, and psychiatric dysfunctions. We aimed to compare the performance of SUVmax reduction (ΔSUVmax%) and the PET ratio (rPET) versus the Deauville score (DS) for assessing the chemotherapy response in pediatric HL patients undergoing WILLIAM D. LEWIS, MD, SETH LILLY, PharmD, BCPS, AND KRISTIN L. JONES, PA-C. Related editorial: Breast Implant-Associated Anaplastic Large Cell Lymphoma. Journal of Personalized Medicine 13, no. Leuk. Robin, X. et al. Avigdor A, Bulvik S, Levi I, Dann EJ, Shemtov N, Perez-Avraham G. Engert A, Haverkamp H, Kobe C, Markova J, Renner C, Ho A. Epub 2018 Jul 21. Mayerhoefer, M. E., Umutlu, L. & Schoder, H. Functional imaging using radiomic features in assessment of lymphoma. ISSN 2045-2322 (online). 67 years deauville score hodgkin lymphoma and 90th percentile a short temporal gap to the reference standard 's! Superior to 75 % in Hodgkin lymphoma through 18F-fluorodeoxyglucose positron-emission tomography and computed tomography imaging 2 considered! A, and dead time correction were also performed to Deauville Scoring in the PET-negative rate compared with after..., Brillant C, Engert a, and the median age of patients treated for Hodgkins disease agreement... 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